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Top 10 most-read blog posts of 2012: #5
How antipsychotics cause side effects such as obesity and diabetes Originally published January 31, 2012 In 2008, roughly 14.3 million Americans were taking antipsychotics—typically prescribed for...
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Top 10 most-read blog posts of 2012: #4
Rare bone disorder reveals new insights into autism Originally published March 12, 2012 Children with multiple hereditary exostoses (MHE), an inherited genetic disease, suffer from multiple growths on...
View ArticleRare Disease Day 2013: live webcast
February 28 is Rare Disease Day and you’re invited to join our fourth annual Rare Disease Day Symposium by live webcast. When: February 28, 2013, 8:30 a.m. – 5:30 p.m. PST Where: Live at...
View Article3 common health conditions that are benefiting from rare disease research
Today we held our fourth annual symposium marking Rare Disease Day. As keynote speaker William A. Gahl, M.D., Ph.D., noted, “it takes a village” to diagnose, treat, and care for people with rare...
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Building “mini muscles” from stem cells
To make “mini muscles” from stem cells, you need the protein BAF60C. Pier Lorenzo Puri, Ph.D., and his team study what makes a muscle cell just that—a muscle cell. They’re especially interested in...
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Children with rare disease CDG don’t have mutation in every cell type
Children born with rare, inherited conditions known as Congenital Disorders of Glycosylation, or CDG, have mutations in one of the many enzymes the body uses to decorate its proteins and cells with...
View ArticleVIDEO: Our inspiration for CDG research
Also check out our latest Beaker post on our CDG research.
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Researchers develop novel nanoparticle to deliver powerful RNA interference...
Silencing genes that have malfunctioned is an important approach for treating diseases such as cancer and heart disease. One effective approach is to deliver drugs made from small molecules of...
View ArticleA guy named Freeze works in hot springs…but the story is much better than that!
Most people go to Yellowstone National Park to explore the outdoors and admire nature. But in 1966 two scientists named Freeze and Brock went on different mission, not knowing that their journey would...
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A new approach to treating brain cancer
A new experimental approach to treating a type of brain cancer called medulloblastoma has been developed by researchers at Sanford-Burnham. The method targets cancer stem cells—the cells that are...
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Freedom from insulin dependence by regenerating pancreatic beta-cells
Scientists at Sanford-Burnham have published back-to-back papers in the Regenerative Medicine section of the journal Stem Cells, showing how it’s possible to generate new, insulin-producing beta-cells...
View ArticleScientists identify a new component of weaponry that silences genes
Understanding the mechanics of RNA interference (RNAi), a defense phenomenon that silences genes, might one day allow scientists to mimic this natural protective mechanism against viruses and create...
View ArticleEpigenetics 101
Over 400 attendees were recently drawn to Sanford-Burnham’s 35th annual symposium titled “Epigentics: Development and Disease.” So why did so many people come and listen to distinguished scientists and...
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Scientists discover a “tumor-prone” cell that can lead to brain cancer
A new study has revealed a rare cell type that gives rise to a type of brain cancer called medulloblastoma. The unusual cells, called “nestin-expressing progenitors” (NEPs), are more efficient at...
View ArticleMending a broken heart
Scientists at Sanford-Burnham have uncovered the critical switch that directs stem cells to become heart-muscle cells. Until now, the central mechanism that instructs cells to become heart muscle has...
View ArticleDiscovering a “THRIL” that correlates with severity of Kawasaki disease
Sanford-Burnham Medical Research Institute scientists have discovered a new molecule that forms when certain white blood cells—macrophages—are stimulated in response to pathogens. The molecule, termed...
View ArticleRegenerating myelin for multiple sclerosis requires “contactin-1”
A new study has revealed that the glycoprotein “contactin-1” is essential for myelination of the central nervous system (CNS). The findings, published in PNAS, will guide novel approaches aimed to...
View ArticleGlobal research team uncovers little-known disease: phosphoglucomutase-1...
In the United States, rare diseases are classified as those that affect fewer than 200,000 people. There are nearly 7,000 documented rare diseases—and more than 25 million Americans have one. Most rare...
View Article“TUNA” is required for neural stem cell differentiation
Ribonucleic acids (RNAs), the molecules intimately involved in the expression and regulation of genes, comprise a biological landscape with huge amounts of territory unexplored and unknown. On the...
View ArticleSanford-Burnham hosts Fifth Annual Rare Disease Day Symposium
From February 28 until March 1, Sanford-Burnham will host its fifth Annual Rare Disease Day Symposium. This annual international event was originally launched in Europe in 2008 and raises awareness...
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